My scientific program is historically grounded in cardiovascular development. A longstanding interest is in processes that account for ventricular chamber morphogenesis, which includes mechanisms that support cardiomyocyte proliferation, coronary vascularization, and mesenchymal progenitor cell differentiation. More recently, we have increasingly gravitated our attention to the connection between embryonic heart development and postnatal heart biology, and in particular how the postnatal post-injury repair and regenerative response of the heart recapitulates processes that occur in normal development. We primarily study these processes in mice using molecular genetic and genomic strategies.
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